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2,2-Dimethylbutyryl chloride — what buyers really ask about, and what the lab folks actually need If you work in process chemistry or sourcing, you’ve probably seen this one pop up on RFQs: 2,2-Dimethylbutyryl chloride (CAS 5856-77-9 ). It’s not as ubiquitous as pivaloyl chloride, but it carves out a nice niche where a slightly longer, still-bulky acyl fragment is desired. And yes, it’s moisture sensitive and a bit of a diva in the drum—more on storage in a second. Quick context and current trend We’re seeing steady demand from custom synthesis groups and agro innovators who need sterically demanding acylations. Compared with lighter acyl chlorides, this one tends to dial up hydrolytic stability in downstream esters/amides. Some customers say it’s become their “go-to” blocker when they want a bulkier cap but not the full pivaloyl footprint—interesting middle ground, I’d say. Typical specs (real-world values may vary a touch) Parameter Spec (≈ or typical) Name / Synonyms 2,2-Dimethylbutyryl chloride; 2,2-Dimethylbutanoyl chloride CAS 5856-77-9 Molecular formula / weight C6H11ClO; ≈134.60 g/mol Appearance Colorless to pale yellow liquid Purity ≥98.0% (GC-FID) Moisture ≤0.5% (Karl Fischer, ASTM E203) Color ≤50 APHA (ASTM D1209) Boiling range ≈130–140°C (at 1 atm; depends on cut) Density ≈0.98–1.02 g/cm³ (20°C) Packaging 1 kg, 5 kg, 25 kg; sealed, N2 blanket Process notes and QC flow Materials: 2,2-dimethylbutanoic acid, thionyl chloride or oxalyl chloride; catalytic DMF; dry solvent as needed. Method: controlled addition, moisture exclusion, HCl/SO2 venting, and then a careful distillation (reduced pressure) for a clean cut. Testing: GC assay and related substances; KF moisture; color (APHA); identity by IR and 1H/13C NMR; sometimes chloride titration. Standards used commonly include ASTM E203 and D1209, with GMP-aligned documentation (ICH Q7) when supplied as an API intermediate. Service life: unopened drums often hold 18–24 months at 2–8°C under nitrogen; once opened, many teams aim to finish within weeks—water is the enemy here. Applications and advantages Pharma and CDMO work: hindered amide and ester formation where stability matters. Agrochemical intermediates: sterically demanding acyl caps for improved persistence. Materials and coatings: tuning hydrophobicity and steric profiles in specialty resins. Advantages include strong steric bulk without going fully neopentyl, relatively neat distillation behavior, and—surprisingly—good batch-to-batch reproducibility reported by several buyers. Vendor landscape (informal snapshot) Vendor Purity (typ.) Packs Docs Lead time Customization MoneideChem (Origin: 2-7-523 Jidong Building Materials, Tangshan, Hebei 064000 China) ≥98–99% 1–25 kg CoA, SDS, REACH notes Around 1–2 weeks Cut specs, N2 purge options Merck/Sigma-Aldrich ≈97–99% Lab packs CoA, SDS Stock-dependent Limited (catalog) TCI ≈95–99% Lab packs CoA, SDS Fast for small lots Catalog specs Customization and testing Custom GC thresholds, low-acid grades, or tighter APHA limits are common requests. Some projects also ask for additional NMR trace reporting and residual solvent panels per ISO/IEC 17025-tested methods. To be honest, it’s worth asking for a mock CoA early. Two quick case notes Agro intermediate: switching to 5856-77-9 raised isolated amide yield by ≈3–5% under Schotten–Baumann conditions (DIPEA, catalytic DMF), with cleaner GC baseline. Specialty ester: a coatings team reported improved hydrolytic stability versus a lighter acyl chloride—small effect, but enough to pass their salt‑spray spec. Safety snapshot GHS/CLP: corrosive; lachrymator; reacts with moisture to release HCl. Use dry nitrogen, acid-resistant PPE, and vented caps. Check SDS and local regulations before scale-up. Citations European CLP Regulation (EC) No 1272/2008 overview – ECHA. https://echa.europa.eu/regulations/clp/understanding-clp ASTM E203 – Standard Test Method for Water Using Karl Fischer. https://www.astm.org/e0203-16.html ASTM D1209 – Standard Test Method for Color (APHA). https://www.astm.org/d1209-05r11.html ICH Q7 – GMP for Active Pharmaceutical Ingredients. https://www.ich.org/page/q7-good-manufacturing-practice-guide REACH Regulation overview – ECHA. https://echa.europa.eu/regulations/reach